Thesis Title

A Possible Role For Prostaglandin E-B2-S as a Suppressor of Macrophage Phagocytosis

Date of Graduation

Summer 1986

Degree

Master of Science in Biology

Department

Biology

Committee Chair

Richard Myers

Subject Categories

Biology

Abstract

Suppression of macrophage phagocytosis of Listeria monocytogenes has been shown to be due to a low molecular weight component of spleen cell culture supernatant. The possibility that the factor could be a prostaglandin was investigated. When murine peritoneal macrophages were treated with prostaglandin E₂ (PGE₂) they phagocytized L. monocytogenes at a rate comparable to that phagocytized when treated with a low molecular weight fraction of Concanavalin A generated spleen cell culture supernatant. Suppressive activity of spleen cell culture supernatant was abrogated when supernatant was prepared in the presence of indomethacin, a prostaglandin synthetase inhibitor. These results suggest a role for PGE₂ as a modulator of macrophage phagocytosis of L. monocytogenes.

Copyright

© Deborah L Hutchison

Citation-only

Dissertation/Thesis

Share

COinS