Thesis Title

Synthesis, Characterization and Anti-Cancer Properties of Organotin(Iv) Cyanoximates

Date of Graduation

Spring 2004

Degree

Master of Science in Chemistry

Department

Chemistry

Committee Chair

Nikolay Gerasimchuk

Keywords

anti-tumor, tin, cyanoximes, cancer, diorganotin, anti-cancer

Subject Categories

Chemistry

Abstract

In recent years numerous organotin(IV) derivatives exhibited remarkable cytotoxicity against several types of cancer. There was no information, however, about this property for cyanoxime-containing organotin(IV) complexes. Previously, cyanoximes have shown an interesting spectrum of biological activity ranging from growth-regulation to anti-microbial and pesticide detoxification actions. This work presents an attempt to combine useful properties of both groups of compounds for enhancement of possible anti-proliferating activity of new substances. Thus, a series of diphenyl- and dibutyl-tin(IV) complexes with cyanoxime ligands has been prepared and characterized using a variety of spectroscopic methods and x-ray analysis. The metal complexes were studied for anti-proliferating activity using in vitro experiments with human cervical cancer HeLa and WiDR colon cancer cell lines with cisplatin used as a positive control substance.

Copyright

© Tiffany R. Maher

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Dissertation/Thesis

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