Thesis Title

Further Investigations of Cytotoxic Metallo Cyanoximates

Date of Graduation

Spring 2007

Degree

Master of Science in Chemistry

Department

Chemistry

Committee Chair

Nikolay Gerasimchuk

Keywords

anti-tumor, platinum, palladium, cyanoximes, cancer, anticancer

Subject Categories

Chemistry

Abstract

Several compounds of platinum (II, IV) as well as palladium (II) are well-established as inorganic anticancer pharmaceuticals. Substantial biological activity (growth regulating, antimicrobial, anticancer, pesticide detoxifying) has also been demonstrated during the last two decades for the cyanoximes - compounds having general formula NC-C(R)=NOH, where R is an electron withdrawing group. Studies are underway that are directed towards combining the useful properties of both classes of compounds in order to create a new group of antitumor agents. A series of 19 previously unknown bivalent Pd and Pt cyanoximates has been prepared and characterized using spectroscopic and structural methods. The compounds have been tested in vitro against HeLa (cervical) and colon (WiDR) human cancer cell lines using cisplatin as positive control. Screening in vitro allowed selection of cyanoxime ligand that gave metal complexes demonstrating the greatest activities. Stoichiometric M(MCO)₂ (M=Pd, Pt) complexes are comparable in cytotoxicity to cisplatin. DNA binding properties of these compounds has been investigated. They will be further investigated on other cell lines and then tested in animal models.

Copyright

© Jessica L. Ratcliff

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Dissertation/Thesis

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