Date of Graduation

Spring 2015

Degree

Master of Science in Chemistry

Department

Chemistry

Committee Chair

Reza Herati

Keywords

copolymer, dendrimer, PEG, micelle, drug delivery, phase transfer catalyst, gene delivery

Subject Categories

Chemistry

Abstract

In this work, I have synthesized a series of poly(ethylene glycol)-block-polyamide dendrimers and have characterized them by NMR spectroscopy. I have also studied the potential applications of methoxy poly(ethylene glycol)-block-poly(ether sulfide) [or mPEG-block-poly(ether sulfide)] dendrimers in drug delivery by examining the solubility of pyrene in water in the presence of the various concentrations of the dendrimers. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer modestly increased the solubility of pyrene in water. Applications of these dendrimers as phase transfer catalysts have also been investigated. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer acted as an excellent phase transfer catalyst in the dehydrohalogenation of 2-bromoethyl benzene. The effect of mPEG-block-poly(ether sulfide) dendrimer on calf-thymus DNA has also been investigated by circular dichroism (CD). Finally, the effects of mPEG and mPEG-block-poly(amido amine) dendrimers on Dickerson-Drew Dodecamer DNA have been studied by NMR spectroscopy and CD and the results are presented and discussed.

Copyright

© Xiaozheng none Dou

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