Thesis Title

Electrogenerated Chemiluminescence Quenching Of Ru(Bpy)32+ In The Presence Of Acetaminophen, Acetylsalicylic Acid And Their Metabolites

Date of Graduation

Spring 2005

Degree

Master of Science in Chemistry

Department

Chemistery

Committee Chair

Mark Richter

Keywords

electrogenerated chemiluminescence, ruthenium, photoluminscence, pharmaceuticals, analytical chemistry

Subject Categories

Chemistry

Abstract

Quenching of Ru(bpy)3,2+ (bpy = 2,2̀-bipyridine) electrogenerated chemiluminescence (ECL) has been observed in the presence of acetaminophen and related complexes. In most instances, quenching is observed with 100-fold excess of acetaminophen and its metabolite (as compared to ECL luminophore) with complete quenching observed between 8,000 and 10,000 fold excess. No quenching is observed with acetylsalicylic acid but quenching is observed for its metabolites. Photoluminescence and UV-Vis experiments coupled with bulk electrolysis support for the formation of benzoquinone products upon electrochemical oxidation. The mechanism of quenching is believed to involve energy transfer from the excited state luminophore to benzoquinone species formed upon oxidation at the electrode surface. The use of ECL quenching to detect acetaminophen and acetylsalicylic acid metabolites in commercial samples is also discussed.

Copyright

© Catherine S. Haslag

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Dissertation/Thesis

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