Date of Graduation

Spring 2015

Degree

Doctor of Audiology

Department

Communication Sciences and Disorders

Committee Chair

Wafaa Kaf

Keywords

electrocochleography, continuous loop averaging deconvolution, auditory brainstem response, Ménière's disease, fast click rate, normative data

Subject Categories

Communication Sciences and Disorders

Abstract

The purpose of the study is to provide normative data for fast stimulus rate electrocochleography (ECochG) and auditory brainstem response (ABR) using the continuous loop averaging deconvolution (CLAD) technique, and to provide pilot data for Meniere's disease. Extra-tympanic ECochG and ABR were recorded simultaneously using a 2-channel recording at 85 dB nHL with alternating polarity using fast click rates ranging from 7.1 to 507 clicks/second in 21 healthy adults and 3 Meniere's patients. The averaged summating potential (SP), action potential (AP), and ABR waves I, III, and V amplitudes and latencies, and SP/AP amplitude ratio, were compared within subjects as a function of rate, and then compared between groups. Normative data showed an increase in latency and decrease in amplitude with increasing rate for AP and waves I, III, and V. However, the SP latency and amplitude remained stable with increasing rate. Similar trends were found for the Meniere's patients, except AP latency was more prolonged (increased 0.70 ms from 7.1/s to 507/s) compared to the increased 0.39 ms in the normative group. This study provides normative data for CLAD ECochG and ABR, and it would be feasible to investigate the AP and ABR wave I increased latency differences with a larger sample size of Meniere's patients.

Copyright

© Samantha Michelle Dixon

Campus Only

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