Title

Influence of Cowpea (Vigna unguiculata) Peptides on Insulin Resistance

Document Type

Article

Publication Date

2015

Keywords

insulin signaling, cowpea peptides, anti-diabetic agent, health-promoting bioactives

Abstract

Biomolecules from cowpea (Vigna unguiculata) can be beneficial in the reduction of hyperglycemia and strengthening the antioxidant status of individuals with diabetes. L6 rat skeletal muscles were exposed to various doses of cowpea peptides (0.1, 1, 10 and 100 ng) for 20 hours or insulin (100 nM) for 30 minutes. Proteins were isolated from the treated cells and analyzed by Western blot for the phosphorylation of Akt (a form of protein kinase B; PKB). Study findings show that the cowpea peptides can induce Akt phosphorylation in the cell culture. This indicates that administering the cowpea peptides to the skeletal muscle cells can activate the insulin signaling cascade. It is probable that cowpea peptides can mimic the actions of insulin by activating the same signaling cascade.

Recommended Citation

Barnes, M., F. Uruakpa, and C. Udenigwe. "Influence of cowpea (Vigna unguiculata) peptides on insulin resistance." J Nutr Health Food Sci 3 (2015): 1-3.

DOI for the article

10.15226/jnhfs.2015.00144

Department

Biomedical Sciences

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