Title

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

Document Type

Article

Publication Date

2010

Keywords

gold, nanoparticles, nanomaterials, RNA, nucleic acid

Abstract

Nanotechnology has virtually exploded in the last few years with seemingly limitless opportunity across all segments of our society. If gene and RNA therapy are to ever realize their full potential, there is a great need for nanomaterials that can bind, stabilize, and deliver these macromolecular nucleic acids into human cells and tissues. Many researchers have turned to gold nanomaterials, as gold is thought to be relatively well tolerated in humans and provides an inert material upon which nucleic acids can attach. Here, we review the various strategies for associating macromolecular nucleic acids to the surface of gold nanoparticles (GNPs), the characterization chemistries involved, and the potential advantages of GNPs in terms of stabilization and delivery.

Recommended Citation

DeLong, Robert K., Christopher M. Reynolds, Yaneika Malcolm, Ashley Schaeffer, Tiffany Severs, and Adam Wanekaya. "Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules." Nanotechnology, science and applications 3 (2010): 53.

DOI for the article

10.2147/nsa.s8984

Department

Biomedical Sciences

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