Effects of tannic acid on Drosophila larval salivary gland cells
Drosophila funebris larvae were grown on media of 1, 10, 100, and 1000 ppm tannic acid, a constituent of many fruits and vegetables upon which Drosophila breed and develop. All tannic acid treatments induced cytoplasmic alterations in the larval salivary gland cells. Concentrations of 10, 100, and 1000 ppm tannic acid induced nucleolar hypertrophy that resulted in a highly significant reduction in the nuclear to nucleolar diameter ratio. Apparently tannic acid binding did not allow normal ribosomal RNA metabolism.
Kreber, Robert A., and Frank A. Einhellig. "Effects of tannic acid on Drosophila larval salivary gland cells." Journal of insect physiology 18, no. 6 (1972): 1089-1096.
Journal of Insect Physiology