Sorgoleone from root exudate inhibits mitochondrial functions
The aim of this investigation was to determine if sorgoleone (SGL), a hydrophobic compound in Sorghum bicolor (L.) Moench root exudate, interferes with mitochondrial functions. Tests were conducted on mitochondria isolated from etiolated soybean [Glycine max (L.) Merr.] and corn (Zea mays L.) seedlings. The data show SGL is a potent inhibitor of state 3 and state 4 respiration rates in both soybean and corn. Using either NADH, succinate, or malate as substrate, the I50 was about 0.5 μM SGL for state 3 and 5.0 μM for state 4 based on 0.3-0.5 mg mitochondrial protein. Absorption spectra indicate SGL blocks electron transport at the b-c1 complex. These data show that disruption of mitochondrial function may be a mechanism of SGL-mediated growth inhibition previously reported and demonstrate a probable role of SGL in Sorghum allelopathy.
allelochemical, allelopathy, electron transport, inhibitor, mitochondria, root exudate, Sorghum bicolor, Sorgoleone
Rasmussen, James A., Angela M. Hejl, Frank A. Einhellig, and John A. Thomas. "Sorgoleone from root exudate inhibits mitochondrial functions." Journal of Chemical Ecology 18, no. 2 (1992): 197-207.
Journal of Chemical Ecology