Tannic acid-induced dissociation of pituitary melanocyte-stimulating hormone and adrenocorticotropic hormone levels
1. Tannic acid was fed to young male and female laboratory mice at an 8% concentration (wt/wt) in ground food for 5 or 10 weeks duration.
2. Bioassays of pituitary melanocyte-stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) levels at autopsy revealed significantly elevated levels of pituitary MSH accompanied by significantly reduced levels of pituitary ACTH.
3. The results confirm a suspected dissociation of pituitary secretion of MSH and ACTH.
Egge, Paul R., Margaret H. Peaslee, and Frank A. Einhellig. "Tannic acid-induced dissociation of pituitary melanocyte-stimulating hormone and adrenocorticotropic hormone levels." General Pharmacology: The Vascular System 9, no. 1 (1978): 33-35.