Tannic acid-induced dissociation of pituitary melanocyte-stimulating hormone and adrenocorticotropic hormone levels

Abstract

1. Tannic acid was fed to young male and female laboratory mice at an 8% concentration (wt/wt) in ground food for 5 or 10 weeks duration.

2. Bioassays of pituitary melanocyte-stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) levels at autopsy revealed significantly elevated levels of pituitary MSH accompanied by significantly reduced levels of pituitary ACTH.

3. The results confirm a suspected dissociation of pituitary secretion of MSH and ACTH.

Document Type

Article

DOI

https://doi.org/10.1016/0306-3623(78)90055-1

Publication Date

1-1-1978

Journal Title

General Pharmacology

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