Title

From membranes to organelles: emerging roles for dynamin-like proteins in diverse cellular processes

Document Type

Article

Publication Date

2014

Abstract

Dynamin is a GTPase mechanoenzyme most noted for its role in vesicle scission during endocytosis, and belongs to the dynamin family proteins. The dynamin family consists of classical dynamins and dynamin-like proteins (DLPs). Due to structural and functional similarities DLPs are thought to carry out membrane tubulation and scission in a similar manner to dynamin. Here, we discuss the newly emerging roles for DLPs, which include vacuole fission and fusion, peroxisome maintenance, endocytosis and intracellular trafficking. Specific focus is given to the role of DLPs in the budding yeast Saccharomyces cerevisiae because the diverse function of DLPs has been well characterized in this organism. Recent insights into DLPs may provide a better understanding of mammalian dynamin and its associated diseases.

Recommended Citation

Williams, Michelle, and Kyoungtae Kim. From membranes to organelles: emerging roles for dynamin-like proteins in diverse cellular processes." European journal of cell biology 93, no. 7 (2014): 267-277."

DOI for the article

http://dx.doi.org/10.1016/j.ejcb.2014.05.002

Department

Biology

Share

COinS