Title

Insights into eisosome assembly and organization

Document Type

Article

Publication Date

2012

Abstract

Eisosomes, large protein complexes that are predominantly composed of BAR-domain-containing proteins Pil1 and its homologs, are situated under the plasma membrane of ascomycetes. A successful targeting of Pil1 onto the future site of eisosome accompanies maturation of eisosome. During or after recruitment, Pil1 undergoes self-assembly into filaments that can serve as scaffolds to induce membrane furrows or invaginations. Although a consequence of the invagination is likely to redistribute particular proteins and lipids to a different location, the precise physiological role of membrane invagination and eisosome assembly awaits further investigation. The present review summarizes recent research findings within the field regarding the detailed structural and functional significance of Pil1 on eisosome organization.

Recommended Citation

Murphy, E. R., and K. T. Kim. Insights into eisosome assembly and organization." Journal of biosciences 37, no. 2 (2012): 295-300."

DOI for the article

http://dx.doi.org/10.1007/s12038-012-9206-6

Department

Biology

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