Effect of vortex-induced physical stress on fluorescent properties of dye-containing poly(ethylene glycol)-block-poly(lactic acid) micelles
The effect of vortex-induced mechanical stresses on the fluorescent properties of dye-containing poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) block copolymer micelles has been investigated. PEG-b-PLA block copolymer micelles containing fluorescent dyes, 3,3′-dioctadecyloxacarbocyanine perchlorate (DiO) and/or 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI), are prepared by a simple one-step procedure that involves the self-assembly of block copolymers and spontaneous incorporation of hydrophobic dyes into the core of the micelles. Upon vortexing, the micelle dispersion samples showed a decrease in fluorescence intensity in a rotational speed- and time-dependent manner. The results demonstrated that the vortexing can alter the fluorescent properties of the dye-containing PEG-b-PLA block copolymer micelle dispersion samples, suggesting the potential utility of block copolymer micelles as a mechanical stress-responsive nanomaterial.
Chemistry and Biochemistry
micelles, self-assembly, stimuli-sensitive polymers
Odom, Tyler L., Jacob R. Blankenship, Giselle Campos, Devin C. Mart, Wenyan Liu, Risheng Wang, and Keiichi Yoshimatsu. "Effect of vortex‐induced physical stress on fluorescent properties of dye‐containing poly (ethylene glycol)‐block‐poly (lactic acid) micelles." Journal of Applied Polymer Science 138, no. 4 (2021): 49743.
Journal of Applied Polymer Science