2’-Deoxyadenylyl-(3' → 5')-isodideoxyadenosine, a Unique Dinucleotide: Synthesis and Characterization

Tamera S. Jahnke
Vasu Nair


The synthesis, enzymatic stability toward nucleases, and conformational properties of a unique dinucleotide, 2′-deoxyadenylyl-(3′→5′)-isodideoxyadenosine (2), a model system for the terminus of HIV viral DNA on incorporation of the L-related isomeric dideoxynucleoside, (S,S)-IsoddA, is reported. This is the first example of a dinucleotide bearing an isomeric nucleoside component.