Title

2’-Deoxyadenylyl-(3' → 5')-isodideoxyadenosine, a Unique Dinucleotide: Synthesis and Characterization

Abstract

The synthesis, enzymatic stability toward nucleases, and conformational properties of a unique dinucleotide, 2′-deoxyadenylyl-(3′→5′)-isodideoxyadenosine (2), a model system for the terminus of HIV viral DNA on incorporation of the L-related isomeric dideoxynucleoside, (S,S)-IsoddA, is reported. This is the first example of a dinucleotide bearing an isomeric nucleoside component.

Document Type

Article

DOI

https://doi.org/10.1016/0960-894X(95)00386-8

Keywords

synthesis, enzymology, hypochromicity and CD studies of a unique dinucleotide of anti-HIV interest

Publication Date

10-18-1995

Journal Title

Bioorganic and Medicinal Chemistry Letters

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