Abstract

Nanotechnology has virtually exploded in the last few years with seemingly limitless opportunity across all segments of our society. If gene and RNA therapy are to ever realize their full potential, there is a great need for nanomaterials that can bind, stabilize, and deliver these macromolecular nucleic acids into human cells and tissues. Many researchers have turned to gold nanomaterials, as gold is thought to be relatively well tolerated in humans and provides an inert material upon which nucleic acids can attach. Here, we review the various strategies for associating macromolecular nucleic acids to the surface of gold nanoparticles (GNPs), the characterization chemistries involved, and the potential advantages of GNPs in terms of stabilization and delivery. © 2010 DeLong et al.

Department(s)

Biomedical Sciences
Chemistry

Document Type

Article

DOI

https://doi.org/10.2147/NSA.S8984

Rights Information

© 2010 The authors. Publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

Keywords

Gold, Nanomaterials, Nanoparticles, Nucleic acid, RNA

Publication Date

10-7-2010

Journal Title

Nanotechnology, Science and Applications

Share

COinS