The role of inflammasome modulation in virulence
Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology.
Caspase-1, Immune evasion, Immunopathology, Inflammasome, Pathogenicity, Virulence
Lupfer, Christopher R., and Thirumala-Devi Kanneganti. "The role of inflammasome modulation in virulence." Virulence 3, no. 3 (2012): 262-270.