Preparation of molecularly imprinted polymers in supercritical carbon dioxide
Molecularly imprinted polymer nanoparticles were prepared in supercritical carbon dioxide using a noncovalent imprinting approach. In the present work, propranolol was used as a model template, methacrylic acid as a functional monomer, and divinylbenzene as a crosslinker. Under a high dilution condition, the heterogeneous polymerization resulted in discrete crosslinked polymer nanoparticles. Compared with the nonimprinted polymers, the imprinted nanoparticles displayed much higher propranolol uptake in a low polarity organic solvent. The use of a single enantiomer (S) propranolol as the template clearly demonstrated that the imprinted binding sites are chiral-selective, with a cross-reactivity towards (R)-propranolol of less than 5%. The overall binding performance of the imprinted nanoparticles was comparable to imprinted polymers prepared in conventional organic solvents.
Molecular imprinting, Propranolol, Supercritical carbon dioxide
Ye, Lei, Keiichi Yoshimatsu, Dorota Kolodziej, José Da Cruz Francisco, and Estera S. Dey. "Preparation of molecularly imprinted polymers in supercritical carbon dioxide." Journal of applied polymer science 102, no. 3 (2006): 2863-2867.
Journal of Applied Polymer Science