Temperature-responsive "catch and release" of proteins by using multifunctional polymer-based nanoparticles

Abstract

Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive "catch-and-release" of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.

Document Type

Article

DOI

https://doi.org/10.1002/anie.201107797

Keywords

molecular recognition, nanoparticles, phase transitions, polymers, proteins

Publication Date

3-5-2012

Journal Title

Angewandte Chemie - International Edition

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