Temperature-responsive "catch and release" of proteins by using multifunctional polymer-based nanoparticles
Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive "catch-and-release" of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.
molecular recognition, nanoparticles, phase transitions, polymers, proteins
Yoshimatsu, Keiichi, Benjamin K. Lesel, Yusuke Yonamine, John M. Beierle, Yu Hoshino, and Kenneth J. Shea. "Temperature‐Responsive “Catch and Release” of Proteins by using Multifunctional Polymer‐Based Nanoparticles." Angewandte Chemie 124, no. 10 (2012): 2455-2458.
Angewandte Chemie - International Edition