Title

2'-Deoxyadenylyl-(3'→5')-isodideoxyadenosine, a unique dinucleotide: Synthesis, enzymology, and conformational studies

Abstract

The synthesis, enzymatic stability toward nucleases, and conformational properties of a unique dinucleotide, 2'-deoxyadenylyl-(3'→5')-isodideoxyadenosine (2), a model system for the terminus of HIV viral DNA on incorporation of the L-related isomeric dideoxynucleoside, (S,S)-IsoddA, is reported. This is the first example of a dinucleotide bearing an isomeric nucleoside component.

Department(s)

Chemistry

Document Type

Article

DOI

https://doi.org/10.1016/0960-894x(95)00386-8

Keywords

synthesis, enzymology, hypochromicity

Publication Date

1995

Recommended Citation

Jahnke, Tamera S., and Vasu Nair. "2′-Deoxyadenylyl-(3′→ 5′)-isodideoxyadenosine, a unique dinucleotide: Synthesis, enzymology, and conformational studies." Bioorganic & Medicinal Chemistry Letters 5, no. 19 (1995): 2235-2238.

Journal Title

Bioorganic & Medicinal Chemistry Letters

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