2'-Deoxyadenylyl-(3'→5')-isodideoxyadenosine, a unique dinucleotide: Synthesis, enzymology, and conformational studies
Abstract
The synthesis, enzymatic stability toward nucleases, and conformational properties of a unique dinucleotide, 2′-deoxyadenylyl-(3′→5′)-isodideoxyadenosine (2), a model system for the terminus of HIV viral DNA on incorporation of the L-related isomeric dideoxynucleoside, (S,S)-IsoddA, is reported. This is the first example of a dinucleotide bearing an isomeric nucleoside component.
Department(s)
Chemistry and Biochemistry
Document Type
Article
DOI
https://doi.org/10.1016/0960-894x(95)00386-8
Keywords
synthesis, enzymology, hypochromicity and CD studies of a unique dinucleotide of anti-HIV interest
Publication Date
1995
Recommended Citation
Jahnke, Tamera S., and Vasu Nair. "2′-Deoxyadenylyl-(3′→ 5′)-isodideoxyadenosine, a unique dinucleotide: Synthesis, enzymology, and conformational studies." Bioorganic & Medicinal Chemistry Letters 5, no. 19 (1995): 2235-2238.
Journal Title
Bioorganic and Medicinal Chemistry Letters
