Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Abstract

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

Department(s)

Chemistry and Biochemistry

Document Type

Article

DOI

https://doi.org/10.1039/c6tc00122j

Publication Date

2016

Journal Title

Journal of Materials Chemistry C

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