Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery
Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.
He, Shawn, George Tourkakis, Oleg Berezin, Nikolay Gerasimchuk, Hairong Zhang, Haiying Zhou, Asaf Izraely, Walter J. Akers, and Mikhail Y. Berezin. "Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery." Journal of Materials Chemistry C 4, no. 14 (2016): 3028-3035.
Journal of Materials Chemistry C