The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate
Date of Graduation
Master of Science in Biology
Systemic administration of the CCK-A receptor antagonist lorglumide has been shown to block voltammetrically detected dopamine (DA) signals associated with slow wave depolarization (SWD) in the rat caudate (CPu). Failure to elicit KC1-induced DA signals following lorglumide treatment may be due to a CCK-DA interaction. This possibility was investigated in this study using both turnover estimates and microdialysis to evaluate the effects of systemic lorglumide on DA turnover and release in the rat CPu. Turnover estimates based on the depletion of DA following α-mpt or by evaluation of DOPAC/DA ratios failed to reveal a significant difference when lorglumide-treated animals were compared to saline treated controls. Further, lorglumide did not alter basal or KC1-stimulated DA and serotonin release in the CPu as measured by microdialysis. These results suggest that any potential interaction between CCK and DA in the rat CPu is not mediated by CCK-A receptors.
© Kathleen A Kedzie
Kedzie, Kathleen A., "The Effect of Cholecystokinin Antagonist Lorglumide on Dopamine Levels in the Rat Caudate" (1993). MSU Graduate Theses. 152.