Thesis Title

Developing Salicylate-Selective Polymer Membrane Electrodes Based on Lutetium (Iii) Porphyrins

Date of Graduation

Summer 2004


Master of Science in Chemistry


Chemistry and Biochemistry

Committee Chair

Erich Steinle


Ion selective electrodes are utilized in many clinical and environmental settings and are used to measure sodium levels in blood and fluoride concentrations of drinking water. The main challenge with these electrodes is to efficiently and precisely measure a particular ion without being hindered by other interfering species. This has led to the investigation of lanthanide series metals that can be incorporated into metalloporphyrins and utilized as selective ionophores. The initial focus was demonstrating the selectivity of two lanthanide-based metalloporphyrins, gadolinium and lutetium, toward various common anions. This initial work dealt with a broad range of anions and various mediums, but the salicylate anion was chosen due to its superior selectivity by the Lu(III) membranes. Further, to demonstrate possible applications the Lu(III) metalloporphyrin-based ISEs were placed in a synthetic urine medium to analyze salicylate levels of clinical interest, where these ion-selective electrodes continued to exhibit excellent selectivity toward salicylate. Finally, the electrode results were then compared with the Trinder method of salicylate analysis, which is the commonly accepted method for biological salicylate analysis.


lutetium, salicylate, electrode, ion-selective, metalloporphyrin

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