Date of Graduation
Master of Science in Chemistry
copolymer, dendrimer, PEG, micelle, drug delivery, phase transfer catalyst, gene delivery
In this work, I have synthesized a series of poly(ethylene glycol)-block-polyamide dendrimers and have characterized them by NMR spectroscopy. I have also studied the potential applications of methoxy poly(ethylene glycol)-block-poly(ether sulfide) [or mPEG-block-poly(ether sulfide)] dendrimers in drug delivery by examining the solubility of pyrene in water in the presence of the various concentrations of the dendrimers. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer modestly increased the solubility of pyrene in water. Applications of these dendrimers as phase transfer catalysts have also been investigated. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer acted as an excellent phase transfer catalyst in the dehydrohalogenation of 2-bromoethyl benzene. The effect of mPEG-block-poly(ether sulfide) dendrimer on calf-thymus DNA has also been investigated by circular dichroism (CD). Finally, the effects of mPEG and mPEG-block-poly(amido amine) dendrimers on Dickerson-Drew Dodecamer DNA have been studied by NMR spectroscopy and CD and the results are presented and discussed.
© Xiaozheng none Dou
Dou, Xiaozheng none, "Synthesis, Characterization, and Applications of Dendrimers" (2015). MSU Graduate Theses. 1999.