A Possible Role For Prostaglandin E-B2-S as a Suppressor of Macrophage Phagocytosis
Date of Graduation
Summer 1986
Degree
Master of Science in Biology
Department
Biology
Committee Chair
Richard Myers
Abstract
Suppression of macrophage phagocytosis of Listeria monocytogenes has been shown to be due to a low molecular weight component of spleen cell culture supernatant. The possibility that the factor could be a prostaglandin was investigated. When murine peritoneal macrophages were treated with prostaglandin E₂ (PGE₂) they phagocytized L. monocytogenes at a rate comparable to that phagocytized when treated with a low molecular weight fraction of Concanavalin A generated spleen cell culture supernatant. Suppressive activity of spleen cell culture supernatant was abrogated when supernatant was prepared in the presence of indomethacin, a prostaglandin synthetase inhibitor. These results suggest a role for PGE₂ as a modulator of macrophage phagocytosis of L. monocytogenes.
Subject Categories
Biology
Copyright
© Deborah L Hutchison
Recommended Citation
Hutchison, Deborah L., "A Possible Role For Prostaglandin E-B2-S as a Suppressor of Macrophage Phagocytosis" (1986). MSU Graduate Theses/Dissertations. 139.
https://bearworks.missouristate.edu/theses/139
Dissertation/Thesis
