Thesis Title

Orally Induced Tolerance to Streptococcus Mutans and Glucosyltransferase in Neonatal Mice

Date of Graduation

Spring 1981

Degree

Master of Science in Biology

Department

Biology

Committee Chair

Richard Myers

Subject Categories

Biology

Abstract

Three antigens, glucosyltransferase (GTase), formalin killed Streptococcus mutans cells (vaccine) and bovine serum albumin (BSA), were used to orally induce tolerance in neonatal C57BL mice. Radial immunodiffusion was used to measure the antibody response to vaccine and BSA, and an enzyme inhibition assay was employed to measure GTase antibody titer. Daily feeding during the first eight days of life resulted in a lower antibody response to the antigens upon subsequent challenge.

Copyright

© Kay Ellen Sterner

Citation-only

Dissertation/Thesis

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