Title

A Comparison of the mismatch negativity and a differential waveform response

Document Type

Article

Publication Date

2005

Keywords

auditory event-related potentials, mismatch negativity, neural recovery

Abstract

A mismatch negativity response (MMN) and a new differential waveform were derived in an effort to evaluate a neural refractory or recovery effect in adult listeners. The MMN was elicited using oddball test runs in which the standard and deviant stimuli differed in frequency. To derive the differential waveform, the same standard and deviant stimuli were presented alone. MMN responses were obtained by subtracting the averaged responses to standards from the deviants. The differential waveforms were obtained by subtracting the averaged responses to standards presented alone from deviants presented alone. Scalp topography for the MMN and differential waveforms were similar. A significant (p<.05) positive and negative correlation was found between the earlier and later components of the bimodal MMN and the N1 and P2 component of the differential waveform, respectively. Further, N1 and P2 of the differential waveform were significant (p<.05) predictor variables of early and late peak amplitudes of the MMN. These results suggest that refractory effects may overlay/modify the morphology of the MMN waveform.

Recommended Citation

Elangovan, Saravanan, Jerry L. Cranford, Letitia Walker, and Andrew Stuart. "A comparison of the mismatch negativity and a differential waveform response: La comparación de la negatividad desigual (mismatch negativity) y de una respuesta de onda diferencial." International journal of audiology 44, no. 11 (2005): 637-646.

DOI for the article

10.1080/00222930500271564

Department

Communication Sciences and Disorders

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