Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention: A randomized controlled study


Objective: To determine if elevated plasma γ′-fibrinogen, typically involved in the formation of fibrinolysis-resistant clots, confers an increased risk for cardiovascular disease (CVD) and thrombosis in children as it does in adults. Although obesity-related hyperfibrinogenemia is frequently reported in children, the role of γ′ fibrinogen and its response to physical activity-based lifestyle are less clear in this population.

Study design: In a randomized controlled 3-month physical activity-based lifestyle intervention, γ′ fibrinogen concentration was measured in 21 children (aged 14-18 years; Tanner stage > IV), including 15 in the obese group and 6 in the normal weight group, with body mass index percentiles for age and sex of >95 and <85, respectively.

Results: The relationships between γ′ fibrinogen and other risk factors for CVD, such as markers of insulin resistance and subclinical inflammation, along with body composition (as measured by dual-energy X-ray absortiometry), were assessed before and after the intervention. γ′ fibrinogen concentration was higher in the obese group compared with the normal weight group (P <.05) and was correlated with other risk factors for CVD (adjusted R2 = 0.9; P <.05), and insulin emerged as the major predictor of γ′ fibrinogen. The intervention reduced γ′-fibrinogen concentration (P <.05).

Conclusion: Our data reveal: (1) elevated γ′ fibrinogen concentrations in obese insulin-resistant children compared with normal lean controls; (2) a relationship between γ′ fibrinogen and other CVD risk factors; and (3) physical activity-induced reduction in γ′ fibrinogen in obese children.


Biomedical Sciences

Document Type





BMI, Body mass index, Bovine serum albumin, BSA, C-reactive protein, Cardiovascular disease, CRP, CVD, DEXA, Dual-energy X-ray absorptiometry, HOMA-IR, Homeostasis model of assessment-insulin resistance, IL, Interleukin, PBS, Phosphate-buffered saline

Publication Date


Journal Title

Journal of Pediatrics