Electronically-Controlled Drug Release System to Promote Wound Healing


A controlled drug release system based on biocompatible and electroactive polymers (EAP) was built to promote wound healing. Negatively-charged as well as positively-charged drugs were loaded into EAP systems through electro-polymerization in the presence of prepolymer and supporting electrolytes. Release was precisely controlled by applying an electrical stimulus. For example, a negative potential applied to change the EAP from its oxidized state to its reduced state resulted in the release of the pre-loaded negatively-charged drugs from the polymer films into the surrounding solution. Additional work included miniaturization of me controlled release system into a two-electrode system with coin cell power source. Step-wise release of two negatively charged compounds (salicylate, a model compound, and Ibuprofen sodium salt, an anti-inflammatory agent) and one positively charged anti-bacterial drug (lincomycin) has been demonstrated. The evidence supports the use of EAPs in a localized therapeutic delivery device for the enhancement of wound healing.



Document Type

Conference Proceeding


Controlled drug release system, Electroactive polymer, Ibuprofen, Lincomycin, Wound healing

Publication Date


Journal Title

Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012