Roni Balzam

Date of Graduation

Spring 2016

Degree

Master of Science in Chemistry

Department

Chemistry and Biochemistry

Committee Chair

G. Alan Schick

Abstract

More than 40% of new chemicals developed in the pharmaceutical industry have poor solubility in aqueous solutions. Active Pharmaceutical ingredients (API) cannot reach their molecular targets in the body if the drug remains undissolved in the gastrointestinal system. One way to approach this problem is by using solubilizing agents. One such agent is a thermo-responsive, tri-block co-polymer which is marketed as “Soluplus®" (SP) by BASF Corporation. A part of this project is to thoroughly characterize various phase properties of SP such as cloud points and gel points temperatures. In current application, SP was incorporated into the creams formulations as an emulsifier to determine the effects on API solubility. The analysis included centrifugations and UVVis studies to determine the concentrations of the API in the cream’s phases. The results of the cloud and the gel points of SP curves matched the curves from polymers containing the individual building blocks of SP. The results of the current application showed that the presence of SP in acid and salt Ibuprofen increased the partitioning of API into the water phase.

Keywords

Soluplus (SP), Ibuprofen (Ibp), creams, water phase, oil phase, cloud points temperatures, gel points temperatures, solubility, polymeric micelles

Subject Categories

Chemistry

Copyright

© Roni Balzam

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