Synthesis, Characterization and Anti-Cancer Properties of Organotin(Iv) Cyanoximates
Date of Graduation
Spring 2004
Degree
Master of Science in Chemistry
Department
Chemistry and Biochemistry
Committee Chair
Nikolay Gerasimchuk
Abstract
In recent years numerous organotin(IV) derivatives exhibited remarkable cytotoxicity against several types of cancer. There was no information, however, about this property for cyanoxime-containing organotin(IV) complexes. Previously, cyanoximes have shown an interesting spectrum of biological activity ranging from growth-regulation to anti-microbial and pesticide detoxification actions. This work presents an attempt to combine useful properties of both groups of compounds for enhancement of possible anti-proliferating activity of new substances. Thus, a series of diphenyl- and dibutyl-tin(IV) complexes with cyanoxime ligands has been prepared and characterized using a variety of spectroscopic methods and x-ray analysis. The metal complexes were studied for anti-proliferating activity using in vitro experiments with human cervical cancer HeLa and WiDR colon cancer cell lines with cisplatin used as a positive control substance.
Keywords
anti-tumor, tin, cyanoximes, cancer, diorganotin, anti-cancer
Subject Categories
Chemistry
Copyright
© Tiffany R. Maher
Recommended Citation
Maher, Tiffany R., "Synthesis, Characterization and Anti-Cancer Properties of Organotin(Iv) Cyanoximates" (2004). MSU Graduate Theses. 1868.
https://bearworks.missouristate.edu/theses/1868
Dissertation/Thesis
