Sorgoleone from root exudate inhibits mitochondrial functions
Abstract
The aim of this investigation was to determine if sorgoleone (SGL), a hydrophobic compound in Sorghum bicolor (L.) Moench root exudate, interferes with mitochondrial functions. Tests were conducted on mitochondria isolated from etiolated soybean [Glycine max (L.) Merr.] and corn (Zea mays L.) seedlings. The data show SGL is a potent inhibitor of state 3 and state 4 respiration rates in both soybean and corn. Using either NADH, succinate, or malate as substrate, the I50 was about 0.5 μM SGL for state 3 and 5.0 μM for state 4 based on 0.3-0.5 mg mitochondrial protein. Absorption spectra indicate SGL blocks electron transport at the b-c1 complex. These data show that disruption of mitochondrial function may be a mechanism of SGL-mediated growth inhibition previously reported and demonstrate a probable role of SGL in Sorghum allelopathy.
Document Type
Article
DOI
https://doi.org/10.1007/BF00993753
Keywords
allelochemical, allelopathy, electron transport, inhibitor, mitochondria, root exudate, Sorghum bicolor, Sorgoleone
Publication Date
2-1-1992
Recommended Citation
Rasmussen, James A., Angela M. Hejl, Frank A. Einhellig, and John A. Thomas. "Sorgoleone from root exudate inhibits mitochondrial functions." Journal of Chemical Ecology 18, no. 2 (1992): 197-207.
Journal Title
Journal of Chemical Ecology
