trans-Golgi network-bound cargo traffic

Abstract

Cargo following the retrograde trafficking are sorted at endosomes to be targeted the trans-Golgi network (TGN), a central receiving organelle. Though molecular requirements and their interaction networks have been somewhat established, complete understanding of the intricate nature of their action mechanisms in every step of the retrograde traffic pathway remains unachieved. This review focuses on elucidating known functions of key regulators, including scission factors at the endosome and tethering/fusion mediators at the receiving dock, TGN, as well as a diverse range of cargo.

Department(s)

Biology

Document Type

Article

DOI

https://doi.org/10.1016/j.ejcb.2018.01.003

Keywords

cargo, dynamin, endosome, fission, fusion, fusion, tether, trans-Golgi network

Publication Date

4-1-2018

Journal Title

European Journal of Cell Biology

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