Homologues of anti-HIV active isodideoxynucleosides

Abstract

The synthesis of a homologous series of compounds related to the anti-HIV active class of compounds known as (S,S)-isodideoxynucleosides has been completed by a convergent route using a modified carbohydrate intermediate. This precursor, synthesized from d-glucose, was coupled with a variety of natural purine and pyrimidine bases to regiospecifically and stereospecifically afford the desired new class of compounds. © 1995 Elsevier Science Ltd.

Document Type

Article

DOI

https://doi.org/10.1016/0040-4020(95)00626-J

Keywords

anti-HIV, convergent synthesis, homologues, isodideoxynucleosides

Publication Date

9-18-1995

Journal Title

Tetrahedron

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