Synthesis of new poly(ethylene glycol)-block-poly(ester sulfide) dendrimers

Abstract

The design and synthesis of novel copolymers that consist of a linear polyoxyethylene block and a dendrimeric poly(ester-sulfide) block with potential applications in drug delivery are described. The dendrimers bear hydroxyl or acrylate functional groups and were prepared via a divergent approach using readily available methoxypoly(ethylene glycol) (mPEG), acryloyl chloride, and 1-thioglycerol as building blocks. All reactions involved occurred efficiently and purification steps consisted of washing the reaction mixture with aqueous solutions and precipitation of the product in diethyl ether.

Department(s)

Chemistry and Biochemistry

Document Type

Article

DOI

https://doi.org/10.1016/j.tetlet.2009.04.138

Publication Date

2009

Journal Title

Tetrahedron Letters

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