The Epigenomic Impact of Quantum Dots: Emerging Biosensors and Potential Disruptors

Abstract

Quantum dots (QDs) have emerged as powerful tools in biomedical applications due to their unique optical and fluorescent properties which enable highly sensitive and multiplexed detection of biomolecules. Particularly in the field of epigenetic research, QDs are utilized as biosensors for monitoring changes in DNA methylation, microRNA (miRNA) expression, and histone modifications, providing a viable alternative to conventional assays. However, increasing evidence also suggests that QDs act as an epigenetic disruptor, altering epigenetic mechanisms and downstream cellular processes. This dual role raises important questions about the safety, reliability, and translational potential of QDs in clinical usage. Therefore, in this commentary we critically evaluate the advances of QD-based epigenetic sensing platforms while also providing insights into QD-based epigenetic dysregulation. We further discuss the current limitations and provide future directions to gain a better understanding of how QDs function to bridge the gap between their diagnostic potential and clinical integration.

Department(s)

Biology

Document Type

Article

DOI

10.3390/epigenomes9040050

Keywords

biosensor, dual role, epigenetic disruptor, epigenetics, quantum dots

Publication Date

12-1-2025

Journal Title

Epigenomes

Link to Full Text

Share

COinS