Date of Graduation
Summer 2012
Degree
Master of Science in Chemistry
Department
Chemistry and Biochemistry
Committee Chair
Reza Herati
Abstract
In this work a mPEG(5000) block poly(ether sulfide) dendrimer was functionalized with glutathione, cysteamine, methyl 3-mercaptopropionate, ethylene diamine, 5-hydroxy-2-phenyl-[1,3]-dioxane, and 5-methyl-2-(2,4,6-trimethoxyphenyl)-[1,3]-5-dioxanylmethanol. The derivatives were characterized using NMR and the critical micelle concentration of several derivatives was measured using fluorescence spectroscopy using pyrene. The degradation of 5-hydroxy-2-phenyl-[1,3]-dioxane, and 5-methyl-2-(2,4,6-trimethoxyphenyl)-[1,3]-5-dioxanylmethanol was monitored by measuring the release of encapsulated Nile red dye using fluorescence spectroscopy at pH 5.0 and 7.4. An mPEG (5000) block poly(amino sulfide) dendrimer was synthesized using thiol-ene and epoxy-amine click chemistry and characterized using NMR. The starting materials used were cysteamine hydrochloride, allyl glycidyl ether and mPEG-NH2.
Keywords
dendrimers, PEGylation, linear dendritic copolymers, PEG, critical micelle concentration, nuclear magnetic resonance, fluorescence spectroscopy
Subject Categories
Chemistry
Copyright
© Jacob Michael Robison
Recommended Citation
Robison, Jacob Michael, "The Synthesis and Characterization of Pegylated Dendrimers" (2012). MSU Graduate Theses/Dissertations. 1983.
https://bearworks.missouristate.edu/theses/1983
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